Process of preparing mercury salts of complex organic bismuth acids and the products obtainable therefrom



@atented New. ll, ieae.

UT STAg WELM KOLLE, HUGO BAUER, AND ERNST MASCHMANN, OF FBANKFORT-U N THE MAIN, GERMANY, ASSIGNOBS TO FARBWERKE VORIVI. MEISTER LUCIUS & BRll N- ING', OF HOCHST-ON-THE-MAIN, GERMANY, A CORPORATION OF GERMANY.

rcnss or PREPARING MERCURY SALTS or coMrLnx oneamc srsrrurrr ACIDS AND THE PRODUCTS OBTAINABLE TEFROM.

Ito Drawing.

To all whom it may concern.

Be it known that we, WILHELM K LLE,

HUGO BAUER, and ERNST llTASCHMANN, citizens of Germany, residing at Frankfort-one the-Main, Germany, have invented certain new and useful Improvements in Processes of Preparing Mercury Salts of Complex Organic Bismuth Acids and the Products Obtainable Therefrom, of which the following is a specification.

We have found that complex bismuth compounds of organic acids, for instance the polyoxycarboxylic acids or nucleic acids, when combined with mercury salts form compounds which may be regarded as mercury salts of complex organic bismuth acids. These new compounds can be prepared by causing the alkali salts of complex organic bismuth acids, such as the bismuthyltartrate of potassium (s. Zeitschrift fiir anorganische Chemie 48,208 1906-) or the complex bismuth salts of polyoxycarboxylic acids, which may be obtained by adding polyoxycarboxylic acids or their alkali salts to a solution of a bismuth salt containing an excess of mineral acid, and by causing the hydrolytic separation of the bismuth salt by the addition of water, combined, it necessary,

with the addition of acid binding means, to

react with salts ofthe monovalent or bivalent mercury. If the complex organic bismuth acids are capable of being mercurated, or if the contain groups which, as for instance t e amino group, are capable of bindin mercury in a complex manner, the possibi ity arises of combining mercury with complex organic bismuth acids with the effect of obtaining complex organic compounds of mercury and bismuth; Such com- 40 pounds then contain bismuth as well as mercury in a modified form-i. e. these compounds donot give reactions of mercury or 'bismuth with sodium hydroxide.

The preparations in question may be used in the treatment of syphilis. Their toxicity isless than that of the compounds which are free from bismuth but with the same pro- Appllication filedJanuary 23, 1923. Serial No. 614,4?0.

portion otmercury; on the other hand, the tests on animals shows that the therapeutical efliciency of the bismuth is increased by the ing about 40 per cent of bismuthand 34 per cent of mercury.

2. 4.1 gr. of basic bismuth gallate are dissolved in 15 com. of water and 10 0. cm. of double normal caustic soda solution and combined with a solution of 2.7 gr. of mercuric chloride in 0. cm. of water. By pourin the clear solution into alcohol a brownish-re precipitate forms which, after being dried, contains 31.8 per cent of mercury and 31.7 per cent of bismuth. The substance thus obtained is soluble in caustic soda solution, and consequently it contains the bismuth as well as the mercury in modified form.

3. 5 gr. of bismuthylnucleic acid are dissolved in 150 0. cm. of water and in such a quantity of double normal caustic soda solution that a neutral solution results which is then mixed with a solution of 0.9 gr. of

able by the action of mercury salts upon solutions of the, alkali salts of complex organic bismuth acids, the new products bein therapeutically eflicient in the treatment 0' syphilis and less toxic than the compounds which are free from bismuth containing the same proportion of mercury, and in which the therapeutical action of the bismuth is increased by the mercury component.

In testimony whereof, We afi'ixour signa- 10 tures.

WILHELM KQLLE. HUGO BAUER. ERNST MASCHMANN. Witnesses BAsIL E. SAVARD, G. O. L B. WYLES. 

